Even after nearly a year of its own global invasion that the SARS-Cov-2 virus called COVID-19 continues to enjoy an advantage over humanity that’s not surprising thinking about the unprecedented catastrophe caused by a virus barely known to anyone, its apparently selective approach concerning mildness or severity of the disease, baffling all healthcare scientists and physicians. Humankind, at its current very advanced phase of the research search, is not a celebration to take defeat, and so, the pursuit has been going on around for a successful vaccine, and at the meantime intent study on anti or anti-malarial repurposed medication, plasma treatment along with other potential procedures of therapy. The most important concern of efforts being to reduce the mortality rates that also disagree country-wise and strangely, and until now it was an accepted fact that there’s not any cure for the illness. Various vaccine jobs in a variety of phases of growth are in full swing in a variety of nations with the majority of them promising a vaccine from the brand new year or two early next season. Now, the hottest disappointing developments on therapy approaches practiced so much have introduced the most important question: is a successful vaccine just hope for humanity?
The majority of us recall the dire global craving to get an essentially Indian anti-malarial medication named Hydroxychloroquine (HCQ) as soon as the pandemic was raging furiously in Europe and the US, along with the US President visiting the extent of threatening India when supplies of HCQ were not. But slowly over time that this medication was found unsuccessful and a little harmful also regarding natural immunity. Then there were other steroids and drugs which were utilized with apparently hopeful benefits, Remdesivir function as sole most welcomed one as a life-saver.
The outcomes of this Solidarity Clinical Trial, among the biggest global Randomized Controlled Trials (RCT), that’s been conducted by the World Health Organization (WHO) since March 2020 were announced lately which indicated four of their most promising medication as unsuccessful in reducing mortality. The four appraised therapy procedures, HCQ, Remdesivir, Lopinavir or Ritonavir, and Interferon, are found to have little if any effect on mortality prices. So far as the RCTs conducted in a variety of countries of the world including in China are worried there have always been doubts about their own findings, and specialists believe the need for more such research. Objections were raised from the Solidarity Trial in addition to it pertains to its own sampling methodology from several quarters, with a single Indian hospital needing to quit using Remdesivir promising its benefits within the months of their patients. But technically, it usually means that except for Corticosteroids that have been proven successful in treating patients that are critical there’s not any additional deemed treatment procedure, and also it has to be remembered that steroids aren’t suggested for less-severe or overall sufferers.
More disappointing news came from the Indian Council of Medical Research (ICMR) about the effectiveness of this Convalescent Plasma Therapy (CPT), thus far allowed as an investigational treatment in advanced phases of the disorder from India, which entails taking blood plasma out from regained COVID-19 patients and injecting that this antibody-rich infusion into positive patients, especially the severe ones handled in hospitals. Over the weeks it’s been developed to a systematic therapy method creating proper stations of contributions across the countries as infected physicians too made it a point to contribute plasma.
The Director-General of the ICMR announced the outcomes on 20th October 2020 after running its RCT during April-July length of the year covering over 400 hospitals throughout 39 medical centers of the nation. Depending on the outcomes the ICMR has reasoned the CPT fails to reduce the mortality levels or prevent the development of COVID-19 ailments from moderate to severe stages. Adhering to this discovery the Government of India is mulling elimination of CPT out of the COVID-19 protocol for federal clinical management. This is really sad news since CPT is an extremely common technique of COVID-19 treatment from the absence of a successful vaccine.
Pros, however, aren’t convinced about the CPT results stating that it might have had to do with the delay of this extract and the caliber of the antibodies. The CPT is still a remedy method intended only for emergency usage. Anyhow, given all of these findings that the significance of finding a successful vaccine develops even more. The pandemic is far out of maintaining its clutches off humanity however: after more than 6 months of random acceleration, India has reached its peak in the third week of September 2020 with new instances still hovering around fifty million a day and 500+ deaths while the European nations and the US are experiencing another wave.
